Seventy-eight spotted ground squirrels, Xerospermophilus (syn. Spermophilus) spilosoma, from 2 different habitats (grassland and creosote bush) located in central New Mexico, were examined for helminth parasites. Eighteen hosts were negative and from 60 hosts the following helminth parasites were recovered: Acanthocephala: Moniliformis clarki; Nematoda: Citellina triradiata, Dermatoxys veligera, Heteromyoxyuris deserti, Mastophorus dipodomis, Physaloptera massino, Protospirura ascaroidea, Pterygodermatites coloradensis, Subulura novomexicanus, Syphacia eutamii, and Syphacia peromysci; Cestoda: Hymenolepis citelli. The parasites D. veligera, Heteromyoxyuris deserti, Mastophorus dipodomis, Moniliformis clarki, Protospirura ascaroidea, and S. peromysci are recorded for the first time from this host.