Field activities in several localities within the basin of the Doce River, state of Minas Gerais, Brazil, resulted in the collection of a new Ischnocnema that we assign to the I. verrucosa species series. The new species resembles I. verrucosa and I. octavioi by its possession of small digital discs, short legs, conspicuously tuberculate dorsal surfaces, a W-shaped mark between the shoulders with two large tubercles at the bases, and a red iris with a vertical black bar in life. It differs from I. verrucosa and I. octavioi by its possession of externally indistinct tympanum and tympanic annulus and visible white glandular-appearing nuptial pads in males. We also assign I. octavioi and I. penaxavantinho to the I. verrucosa species series.