A new genus of Urodidae, Anomalomeuta gen. nov., is described from Argentina, with the type species, Anomalomeuta dondavisi sp. nov. The new genus is superficially similar to Spiladarcha Meyrick in having scattered small black spots comprised of raised scales along the forewing veins on the upper surface, but it lacks the 2 autapomorphies of the latter genus: a pair of spiniform setal zones on the ventroapical area of the tegumen, and a zone of longitudinal pleats on the ductus bursae. Anomalomeuta also differs from all known urodid genera by the asymmetric valvae in the male genitalia. This characteristic is reported for the first time from Urodoidea and is compared with examples of other Lepidoptera. Keys to all known urodid genera based on the external and male genital features are provided.