The phytosanitary irradiation (PI) literature relating to the genus Anastrepha was analyzed to determine if it was sufficient to support a generic dose < 150 Gy (the accepted generic dose for all of Tephritidae) that could be used on fruit in areas of the tropical and subtropical Americas where only species of the genus are quarantine pests. Although Anastrepha contains > 230 species only 7 have been consistently of quarantine significance, and PI research has been reported on all but one of those. The measure of efficacy for PI of Tephritidae is prevention of adult emergence when eggs or larvae are irradiated in fruit; the 3rd instar is the most radio-tolerant stage. Large-scale testing where ∼100,000 third instars have been treated at one dose with no adults emerging has been successfully conducted at up to 100 Gy with 4 species. However, a rationale for a generic dose of 70 Gy is given based on the apparent homogeneity in response to radiation within the genus and the fact that the International Plant Protection Convention has approved a dose of 70 Gy for 2 key species.