Lepanthopsis kayi, a new species from the Amazonas region in Ecuador, is described, illustrated, compared with similar species, and its generic placement discussed. Lepanthopsis kayi is distinguished from all other species in the genus by the combination of ramicauls shorter than the leaf, with glabrous sheaths with the ribs and ostia thickened, and a very congested inflorescence bearing many overlapping, simultaneous flowers arranged in two opposite-facing ranks, the flowers with a proportionally very large, densely pubescent lip, ca. 50 percent longer than the lateral sepals.