Li, F.; Yao, L.; Sun, W.; Jiang, Y.; Li, Z., and Zhai, Y., 2017. Histopathological liver and testis alterations in male half-smooth tongue sole (Cynoglossus semilaevis) exposed to endocrine disruptors.

Endocrine-disrupting chemicals are a class of xenobiotics that may interfere with the function of the endocrine system. The adverse effects of these substances can be identified through pathology. In this research, the effects of bisphenol A (BPA) or 17β-estradiol (E2) exposure on the liver and testis of Cynoglossus semilaevis were investigated. In particular, this research observed the pathological alterations in the liver (e.g., cellular swelling, hepatocyte adhesion, and vacuolation, etc.) and testis (e.g., cellular swelling, sperm deformation, and flagellum bending, etc.). Results of the investigation revealed that exposure dose and response indicators are correlated with each other, and BPA or E2 exposure at different doses induces some degree of damage to C. semilaevis tissues on a histopathological level. Accordingly, this research provides a window for developing C. semilaevis as a model of marine fish in determining the effects of other kinds of pollutant exposure on the aquatic ecosystem and on humans.