The Mexican bean beetle, Epilachna varivestis Mulsant (Coleoptera: Coccinellidae), is a key pest of beans, and early detection of bean damage is crucial for the timely management of E. varivestis.This study was conducted to assess the feasibility of using drones and optical sensors to quantify the damage to field beans caused by E. varivestis. A total of 14 bean plots with various levels of defoliation were surveyed aerially with drones equipped with red-blue-green (RGB), multispectral, and thermal sensors at 2 to 20 m above the canopy of bean plots. Ground-validation sampling included harvesting entire bean plots and photographing individual leaves. Image analyses were used to quantify the amount of defoliation by E. varivestis feeding on both aerial images and ground-validation photos. Linear regression analysis was used to determine the relationship of bean defoliation by E. varivestis measured on aerial images with that found by the ground validation.The results of this study showed a significant positive relationship between bean damages assessed by ground validation and those by using RGB images and a significant negative relationship between the actual amount of bean defoliation and Normalized Difference Vegetation Index values.Thermal signatures associated with bean defoliation were not detected. Spatial analyses using geostatistics revealed the spatial dependency of bean defoliation by E. varivestis. These results suggest the potential use of RGB and multispectral sensors at flight altitudes of 2 to 6 m above the canopy for early detection and site-specific management of E. varivestis, thereby enhancing management efficiency.