Granulomatous colitis: more than a canine disease? A case of Escherichia coli-associated granulomatous colitis in an adult cat

Rodolfo Oliveira Leal; Kenny Simpson; Mélanie Fine; Jean-Charles Husson; Juan Hernandez

doi:10.1177/2055116917731168

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1 January 2020 Granulomatous colitis: more than a canine disease? A case of Escherichia coli-associated granulomatous colitis in an adult cat

Rodolfo Oliveira Leal, Kenny Simpson, Mélanie Fine, Jean-Charles Husson, Juan Hernandez

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J. of Feline Medicine and Surgery Open Reports, 3(2): (2020). https://doi.org/10.1177/2055116917731168

Abstract

Case summary

This report describes a 4-year-old cat with chronic intermittent haematochezia and faecal incontinence of 7 months’ duration. Investigation revealed severe colonic multifocal mucosal ulcerations and infiltration of the mucosal lamina propria by large numbers of periodic acid–Schiff-positive macrophages. Fluorescence in situ hybridisation analysis of colonic biopsies revealed multifocal clusters of intracellular Escherichia coli. Treatment with fluoroquinolones for 6 weeks led to a complete resolution of clinical signs.

Relevance and novel information

The findings reveal that mucosally invasive E coli can also be associated with granulomatous colitis in cats and indicate the need for diagnostic testing of mucosal samples for E coli and other infectious agents.

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Rodolfo Oliveira Leal, Kenny Simpson, Mélanie Fine, Jean-Charles Husson, and Juan Hernandez "Granulomatous colitis: more than a canine disease? A case of Escherichia coli-associated granulomatous colitis in an adult cat," Journal of Feline Medicine and Surgery Open Reports 3(2), (1 January 2020). https://doi.org/10.1177/2055116917731168

Published: 1 January 2020

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