Although lake whitefish Coregonus clupeaformis populations in the Laurentian Great Lakes have rebounded remarkably from the low abundance levels of the 1960s and 1970s, recent declines in fish growth rates and body condition have raised concerns about the future sustainability of these populations. Because of the ecological, economic, and cultural importance of lake whitefish, a variety of research projects in the Great Lakes have recently been conducted to better understand how populations may be affected by reductions in growth and condition. Based upon our participation in projects intended to establish linkages between reductions in growth and condition and important population demographic attributes (natural mortality and recruitment potential), we offer the following recommendations for future studies meant to assess the health of Laurentian Great Lakes lake whitefish populations: (1) broaden the spatial coverage of comparative studies of demographic rates and fish health; (2) combine large-scale field studies with direct experimentation; (3) conduct multi-disciplinary evaluation of stocks; (4) conduct analyses at finer spatial and temporal scales; (5) quantify stock intermixing and examine how intermixing affects harvest policy performance on individual stocks; (6) examine the role of movement in explaining seasonal fluctuations of disease and pathogen infection and transmission; (7) evaluate sampling protocols for collecting individuals for pathological and compositional examination; (8) quantify sea lamprey-induced mortality; and (9) enact long-term monitoring programs of stock health.