Over a 3-month period, a 6-yr-old, wild-caught, northern leopard frog (Lithobates pipiens) presented for reoccurring cloacal prolapse, despite surgical correction. Two contrast radiographic series performed approximately 6 wk apart showed intestinal obstruction and gastrointestinal dysmotility, while exploratory coeliotomy revealed a minor intestinal intussusception. Approximately 6 months after the fourth and final prolapse had resolved, the animal died of natural causes. Necropsy examination exposed a large, ill-defined thickening of the distal intestinal wall, with proximal intestinal dilation. Histopathology revealed a mass composed of polygonal cells, with occasional intracytoplasmic mucin arranged in sheets, and poorly formed acini, consistent with an intestinal adenocarcinoma. A presumptive metastatic lesion was identified in the kidney (microscopically). Herpesvirus-specific consensus polymerase chain reaction (PCR) and nested PCR assays performed on the formalin-fixed, paraffin-embedded intestinal and kidney masses for ranid herpesvirus 1 were negative. Few reports of intestinal adenocarcinoma in amphibians exist in the literature. To the authors' knowledge, this represents the first report of spontaneous intestinal adenocarcinoma in a northern leopard frog.
How to translate text using browser tools
25 January 2021
Intestinal Adenocarcinoma with Cloacal Prolapse and Reduction in a Northern Leopard Frog (Lithobates pipiens)
Justin M. Stilwell,
Shane M. Boylan,
Whitney Daniel,
Julie Cavin,
Joshua Zalabak,
Alvin C. Camus
ACCESS THE FULL ARTICLE
It is not available for individual sale.
This article is only available to subscribers.
It is not available for individual sale.
It is not available for individual sale.
cloacal prolapse
intestinal adenocarcinoma
Lithobates pipiens
Northern leopard frog