I describe a new species of Liophryne from Cape Nelson, southeastern New Guinea, that is unique in its combination of rather large size, a single-note call emitted from an underground burrow, and absence of vocal slits. This species also has a variety of morphometric and color-pattern features that distinguish it from one or more congeners. The new species is among the more-variable species of Liophryne in dorsal color pattern, being either brown, ochre, or a combination of the two. It is known currently only from the upper elevations of an extinct volcano and may be restricted in distribution to the broader volcanic massif that includes the type locality, inasmuch as this massif appears to have evolved in situ.