Optically Active Arthropod Repellents for Use Against Disease Vectors

Jerome A. Klun; Da Ma; Raj Gupta

doi:10.1603/0022-2585-37.1.182

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Jerome A. Klun,¹ Da Ma,² Raj Gupta³

¹Insect Chemical Ecology Laboratory, USDA–ARS, Beltsville, MD 20705
²Department of Entomology, Walter Reed Army Institute of Research, Washington, DC 20307–5100 and Insect Chemical Ecology Laboratory, USDA–ARS, Beltsville, MD 20705
³U.S. Army Medical Research and Material Command, 504 Scott Street, Fort Detrick, MD 21702–5012 and Insect Chemical Ecology Laboratory, USDA–ARS, Beltsville, MD 20705

Abstract

Optically inactive 1-[3-cyclohexen-1-ylcarbonyl] piperidine and 1-[3-cyclohexen-1-ylcarbonyl]-2-methylpiperidine are repellents against blood-feeding arthropods. Pure stereoisomers of these compounds were synthesized and characterized for use in bioassays. Initial laboratory tests with the malaria vector Anopheles stephensi Liston showed that this species was repelled differentially by the stereoisomers of 1-[3-cyclohexen-1-ylcarbonyl]-2-methylpiperidine. Two stereoisomers were twice as repellent as the other stereoisomers. These results indicate that stereoisomerism influences repellent efficacy in this class of compounds.

Citation Download Citation

Jerome A. Klun, Da Ma, and Raj Gupta "Optically Active Arthropod Repellents for Use Against Disease Vectors," Journal of Medical Entomology 37(1), 182-186, (1 January 2000). https://doi.org/10.1603/0022-2585-37.1.182

Received: 4 May 1999; Accepted: 1 September 1999; Published: 1 January 2000