Mosquitoes that transmit human diseases are of major importance to the international public health community. Pesticides remain a major component of integrated programs to control these medically important species. However, very few types of pesticides are currently registered for mosquito control. A high-throughput screening method using first-instar larvae of Aedes aegypti was created and evaluated in our laboratory to quickly screen large numbers of chemicals for activity against mosquitoes. LC50 values of a representative group of compounds were determined using this high-throughput screening method and compared with LD50 values determined by topical application against female adults of Ae. aegypti. Our results show that this high-throughput screening method is suitable for screening large numbers of candidate chemicals quickly to identify effective compounds.
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1 March 2009
A High-Throughput Screening Method to Identify Potential Pesticides for Mosquito Control
Julia W. Pridgeon,
James J. Becnel,
Gary G. Clark,
Kenneth J. Linthicum
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Journal of Medical Entomology
Vol. 46 • No. 2
March 2009
Vol. 46 • No. 2
March 2009
high-throughput screen
mosquito control
pesticides