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1 March 2009 A High-Throughput Screening Method to Identify Potential Pesticides for Mosquito Control
Julia W. Pridgeon, James J. Becnel, Gary G. Clark, Kenneth J. Linthicum
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Abstract

Mosquitoes that transmit human diseases are of major importance to the international public health community. Pesticides remain a major component of integrated programs to control these medically important species. However, very few types of pesticides are currently registered for mosquito control. A high-throughput screening method using first-instar larvae of Aedes aegypti was created and evaluated in our laboratory to quickly screen large numbers of chemicals for activity against mosquitoes. LC50 values of a representative group of compounds were determined using this high-throughput screening method and compared with LD50 values determined by topical application against female adults of Ae. aegypti. Our results show that this high-throughput screening method is suitable for screening large numbers of candidate chemicals quickly to identify effective compounds.

Julia W. Pridgeon, James J. Becnel, Gary G. Clark, and Kenneth J. Linthicum "A High-Throughput Screening Method to Identify Potential Pesticides for Mosquito Control," Journal of Medical Entomology 46(2), 335-341, (1 March 2009). https://doi.org/10.1603/033.046.0219
Received: 11 January 2008; Accepted: 1 November 2008; Published: 1 March 2009
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KEYWORDS
high-throughput screen
mosquito control
pesticides
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