Preimmunization of mice with salivary gland homogenate (SGH) of long-term colonized (F29) female Phlebotomus papatasi Scopoli (Diptera: Psychodidae) induced protection against Leishmania major Yakimoff & Schokhor (Kinetoplastida: Trypanosomatidae) co-inoculated with the same type of SGH. In contrast, preimmunization of mice with SGH of wild-caught female P. papatasi did not confer protection against L. major co-inoculated with the same type of SGH. Similarly, SGH from recently colonized (F1) female P. papatasi did not protect mice against L. major. These results suggest that when developing a sand fly saliva-based vaccine, the natural vector populations should be considered.
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1 January 2010
Differences in the Salivary Effects of Wild-Caught Versus Colonized Phlebotomus papatasi (Diptera: Psychodidae) on the Development of Zoonotic Cutaneous Leishmaniasis in BALB/c Mice
S. Ben Hadj Ahmed,
I. Chelbi,
B. Kaabi,
S. Cherni,
M. Derbali,
E. Zhioua
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Journal of Medical Entomology
Vol. 47 • No. 1
January 2010
Vol. 47 • No. 1
January 2010
Leishmania major
Phlebotomus papatasi
saliva
vaccine
zoonotic cutaneous leishmaniasis