Use of insecticidal baits risks the evolution of resistance to the feeding stimulant in the bait, not just to the active ingredient (toxicant). Sucrose-based baits are widely used against house flies, Musca domestica L. The baits are applied as dry granules, but readily liquefy. The proboscis extension reflex (PER) and consumption of alternative sweeteners, dry or in solution, were examined. Fructose, glucose, and xylitol merit further study as alternatives to sucrose. Dry, fructose, glucose, and xylitol elicited PER much more than sucrose, although not when in solution. Furthermore, dry or in solution, females and males ate as much or more fructose as sucrose. In solution, flies ate as much glucose as sucrose; although when dry, consumption was much less for glucose than sucrose. Dry, xylitol elicited as much consumption as sucrose for females, though less for males. In solution, for both sexes, xylitol elicited less consumption than sucrose did. Acesulfame potassium, sodium cyclamate, and sucralose do not look promising as they did not often elicit PER, whether dry or in solution. Erythritol also does not look promising. Erythritol elicited PER no more than sucrose did when dry and elicited PER much less than sucrose when in solution. Flies ate much less erythritol than sucrose whether dry or in solution.