Trehalose is a disaccharide that is the major sugar found in insect hemolymph fluid.Trehalose provides energy, and promotes growth, metamorphosis, stress recovery, chitin synthesis, and insect flight. The hydrolysis of trehalose is under the enzymatic control of the enzyme trehalase.Trehalase is critical to the role of trehalose in insect physiology, and is required for the regulation of metabolism and glucose generation. Trehalase inhibitors represent a novel class of insecticides that have not been fully developed. Here, we tested the ability of trehalose analogues to function as larvacides or adulticides in an important disease vector—Aedes aegypti. We show that validamycin A, but not 5-thiotrehalose, delays larval and pupal development and prevents flight of adult mosquitoes. Larval mosquitoes treated with validamycin A were hypoglycemic and pupae had increased levels of trehalose. Treatment also skewed the sex ratio toward male mosquitoes. These data reveal that validamycin A is a mosquito adulticide that can impair normal development of an important disease vector.
How to translate text using browser tools
26 February 2020
Validamycin A Delays Development and Prevents Flight in Aedes aegypti (Diptera: Culicidae)
Andrew D. Marten,
Alicyn I. Stothard,
Karishma Kalera,
Benjamin M. Swarts,
Michael J. Conway
ACCESS THE FULL ARTICLE
It is not available for individual sale.
This article is only available to subscribers.
It is not available for individual sale.
It is not available for individual sale.
Journal of Medical Entomology
Vol. 57 • No. 4
July 2020
Vol. 57 • No. 4
July 2020
adulticide
Aedes aegypti
development
mosquito
trehalose