Mosquito-borne disease (MBD) incidence is increasing in the United States (U.S.), presenting an evolving health threat. Assessments of public perceptions have revealed limited awareness of MBDs among the U.S. population. Our team used focus groups to gain an in-depth understanding of risk perceptions regarding mosquito exposure and pesticide use, and benefit perceptions and motivators for bite prevention strategies. A total of 37 individuals participated in focus groups across 3 states: New Jersey (n = 14), NewYork (n = 15), and Massachusetts (n = 8). Most participants were unfamiliar with public mosquito control services and felt they were not at high exposure risk to any MBDs. Overall, participants were supportive of investing public funds for mosquito surveillance. However, participants across all focus groups expressed concerns over ecosystem health and long-term consequences of pesticide use for mosquito control. Participants in every focus group referenced a risk assessment that weighed the risk of MBD exposure against the use of chemical control: once participants perceived MBDs as negatively impacting human and/or animal health in their area, sentiment swung largely to supporting the use of pesticides. In the absence of an obvious MBD threat, participants preferred nonchemical control interventions. Participants felt communication from mosquito control agencies should be accessible, disseminated across multiple venues, and should include instructions for the public during spray events, resources for individual bite prevention, and information on control products used. Our research results can inform the development of improved, evidence-based MBD outreach and educational resources that are acceptable, actionable, and relevant to Northeast communities.