Patagorbitestella new genus is here proposed to include two extant and one fossil species: P. ponderi (Linse, 2002) new combination, P. patagonica (Simone and Zelaya, 2004) new combination, and P. leonensis new species, the last described from the Punta Entrada Member of Monte León Formation (50°21′25.4”S, 68°53′05.9″W, Aquitanian to lower Burdigalian, lower Miocene). A protoconch sculptured with distinctive microscopic spiral threads serves as a per se diagnostic shell character for the new genus. Patagorbitestella n. gen. constitutes a distinctive lineage of orbitestellid gastropods inhabiting exclusively the Magellanic Region at least since the early Miocene. This is the first fossil record of Orbitestellidae in South America.