Among-deme asynchrony has the potential to influence community richness and diversity by increasing the likelihood of regional persistence for a species. Parasites of Lepomis spp. collected from 4 localities at J. Strom Thurmond Lake, South Carolina over a 1-yr period were used to evaluate patterns of parasite population synchrony. Localities were separated by approximately 5 km to increase the likelihood that the parasites sampled represented different demes. Tylodelphys scheuringi and Crinicleidus longus, exhibited negative covariation between synchrony and among-locality distances. The degree of synchrony exhibited by Neoechinorhynchus cylindratis, Crepidostomum cornutum, and Clavunculus bifurcatus was associated with the degree of similarity in habitat structure between localities. Patterns of synchrony for Posthodiplostomum minimum and Spinitectus sp. were not associated with any of the habitat variables examined. The influence of habitat structure on parasite population synchrony, possibly through the refraction of large-scale environmental drivers, has the potential to produce asynchronous dynamics that are independent of the distance between demes, thereby promoting regional persistence by increasing the likelihood of rescue effects.