LEISHMANIA MAJOR SOLUBLE EXO-ANTIGENS (LmSEAgs) PROTECT NEONATAL BALB/C MICE FROM A SUBSEQUENT CHALLENGE WITH L. MAJOR AND STIMULATE CYTOKINE PRODUCTION BY LEISHMANIA-NAÏVE HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS

Willy K. Tonui; Richard G. Titus

doi:10.1645/GE-782R.1

How to translate text using browser tools

1 October 2006 LEISHMANIA MAJOR SOLUBLE EXO-ANTIGENS (LmSEAgs) PROTECT NEONATAL BALB/C MICE FROM A SUBSEQUENT CHALLENGE WITH L. MAJOR AND STIMULATE CYTOKINE PRODUCTION BY LEISHMANIA-NAÏVE HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS

Willy K. Tonui, Richard G. Titus

Author Affiliations +

J. of Parasitology, 92(5):971-976 (2006). https://doi.org/10.1645/GE-782R.1

Abstract

The vaccine potential and immunogenicity of soluble Leishmania major exo-antigens (LmSEAgs), a potentially novel source for vaccine candidates for leishmaniasis, were evaluated in neonatal BALB/c mice and with human peripheral blood mononuclear cells. Vaccinated neonatal BALB/c mice resisted infection with L. major, and lymphoid cells from the mice proliferated when restimulation with LmSEAgs and produced interferon-γ and some interleukin-4. In addition, LmSEAgs stimulated human peripheral blood mononuclear cells to produce large amounts of interferon-γ and some interleukin-5. This finding suggests that LmSEAgs may be a vaccine candidate for leishmaniasis in humans.

Citation Download Citation

Willy K. Tonui and Richard G. Titus "LEISHMANIA MAJOR SOLUBLE EXO-ANTIGENS (LmSEAgs) PROTECT NEONATAL BALB/C MICE FROM A SUBSEQUENT CHALLENGE WITH L. MAJOR AND STIMULATE CYTOKINE PRODUCTION BY LEISHMANIA-NAÏVE HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS," Journal of Parasitology 92(5), 971-976, (1 October 2006). https://doi.org/10.1645/GE-782R.1

Received: 7 November 2005; Accepted: 1 April 2006; Published: 1 October 2006

KEYWORDS/PHRASES

PUBLICATION TITLE:

COLLECTION:

PUBLICATION YEARS