Relying on the advantages of selenium-rich soil resources, the development of special selenium-rich agricultural industry is an effective measure to implement the rural revitalization strategy. This paper took Yuanzhou district as the research area, based on ecological niche theory, creatively determines the dominant and limiting factors of selenium-rich soil resources development and utilization from three aspects of natural resources endowment, land use conditions and ecological protection, constructed the evaluation index system of selenium-rich soil resources development and utilization and ecological niche suitability index measurement model, and explored the suitability of regional selenium-rich soil resources development and utilization and zoning. The research results show that: (1) The area suitable for exploitation of selenium-rich soil resources in the study area is 174658.4 ha, accounting for 68.83% of the total area, mainly distributed around Yuan River and in the central, northern, northwestern and northeastern areas of the study area. (2) Based on the evaluation results of the suitability of selenium-rich soil resources development and utilization and the development of related agricultural industries, the study area was divided into four functional zones of selenium-rich industrial development: core zone, key zone, development zone and radiation zone. The core zone and key zone are suitable for building selenium-rich agricultural industry demonstration area and selenium-rich products breeding production base, and the development zone and radiation zone can vigorously develop selenium-rich modern agriculture and selenium-rich recreation tourism, which will accelerate the development trend of multi-level and diversified selenium-rich industry in study area.This study can provide scientific, reasonable and feasible ideas and methods for the development and utilization of selenium-rich soil resources and the planning and development of selenium-rich industries in similar areas.