The China-Pakistan Economic Corridor (CPEC) plays an important role in China's ‘Belt & Road Initiative’. It is also one of the most disaster-prone regions in the world. Considering that decentralized disaster governance has been gaining much attention in the world, this paper systematically analyzes the disaster management system in the CPEC region. Specifically, it compares the national, provincial, municipal and community-level institutional mechanisms for disaster management in China and Pakistan, and then closely examines the current trends of decentralized disaster governance based on a recent round of semi-structured and open-ended interviews in Xinjiang, China and Pakistan. Issues and gaps of decentralized disaster governance were drawn out from the experiences of participation among related stakeholders. We found that although the decentralization of the disaster management system has been the main trend in both China and Pakistan, national and provincial disaster management agencies still play a key role in the disaster relief work. Therefore, the centralization and decentralization of disaster management are not contradictory, but the more disaster governance shifts towards decentralization, the more urgent the consolidation of multi-level (vertical) and broader (horizontal) collaboration becomes. Based on this analysis, we aim to provide insights, lessons and recommendations for the way forward for strengthening disaster management in CPEC. In particular, we summarize different but integrated approaches towards effective disaster risk coping strategies and regional cooperation on disaster management in CPEC.