A type of mastery learning was implemented in a sophomore-level genetics major course, using a Blackboard course shell and a premade course cartridge. Students were required to take a series of topical quizzes leading up to the hour lecture exam. However, students could take the quiz as many times as they wished, to earn the grade they wished. Each quiz was unique and drew 10 random questions from a pool. The grades for the mastery learning class were not statistically significantly different from a previous class in which homework assignments were given (P=0.28). However, students were given the option of answering an anonymous survey before each lecture exam; survey results were positive.