The Kentucky Academy of Science was founded in 1914 and now marks its 100th year. In celebration of the event, we have traced its evolution from the beginnings to an organization that now contains more than 2500 members. In 1993, Ted M. George of Eastern Kentucky University published an extraordinary history of the Kentucky Academy of Science covering the first 78 years (1914–1992). He meticulously reviewed Academy archives and back issues of the Journal along with input from a number of long-time Academy members to produce not only the history but also the flavor of the Academy as it grew and matured. Our objective here is not to begin again in documenting the history but to update what George had so nicely produced. Therefore, much of his manuscript has been reproduced verbatim with additions and edits that cover the past 22 years.