Between the early 1970s and to the mid-1990s, David Sanger was largely responsible for a series of large-scale regional survey and excavation projects throughout Passamaquoddy Bay (New Brunswick) and the central/Downeast coasts of Maine. While resulting in an important understanding of the paleoenvironment and prehistoric/historic resource exploitation along the Gulf of Maine, these projects also allowed the development of a unified analytical strategy for the excavation of shell middens using column sampling, documentation, and excavation protocols, as well as sediment analysis and classification. This strategy is detailed below along with a summary of excavations from the Great Spruce Island site (61-17) in the Roque Island Archipelago, Downeast region, ME, USA. Pre-European occupation at this specific site ranges from before 3000 years B.P. to ca. 400 years B.P.