We vaccinated six captive badgers housed with five controls, and monitored blood antibody titers and white cell counts of both groups for 63 days postvaccination between 29 August and 3 December 1992. Five vaccinated badgers responded with antibody titers ranging from 1:64 to 1:1024 by 63 days postvaccination, whereas the sixth badger did not respond. Treatment badgers also had significant (P < 0.05) decreases in lymphocytes on days 16, 29, and 63. No badgers developed clinical signs of distemper. Control badgers did not produce antibodies against CD virus; thus, the vaccine virus probably was not transmitted between treatment and control animals. The vaccine appears safe for use in healthy badgers, but additional safety and efficacy study is needed.