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1 January 1995 EFFICACY OF IVERMECTIN POUR-ON AGAINST OSTERTAGIA OSTERTAGI INFECTION AND RESIDUES IN THE AMERICAN BISON, BISON BISON
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Abstract

Sixteen American bison, Bison bison, were artificially infected with 105 infective stage larvae of Ostertagia ostertagi on 21 April 1993. At 42 days post-infection eight bison were treated with 0.5% ivermectin pour-on (500 μg/kg bodyweight) and eight treated with the carrier only. Bison were necropsied 17 and 18 days post-treatment (21 and 22 June 1993, respectively). Mean (±SE) of 5,413 (±1,716) adults and 565 (±305) immature O. ostertagi were recovered at necropsy from bison treated with the carrier. No O. ostertagi were detected in bison treated with ivermectin pour-on. Based on the levels of the ivermectin marker metabolite in liver and adipose tissue 18 days post-treatment, the established bovine withdrawal time of 48 days appears adequate to insure that violative residues do not occur.

Marley, Knapp, Rognlie, Thompson, Stoppa, Button, Wetzlich, Arndt, and Craigmill: EFFICACY OF IVERMECTIN POUR-ON AGAINST OSTERTAGIA OSTERTAGI INFECTION AND RESIDUES IN THE AMERICAN BISON, BISON BISON
S. E. Marley, S. E. Knapp, M. C. Rognlie, J. R. Thompson, T. M. Stoppa, S. M. Button, S. Wetzlich, T. Arndt, and A. Craigmill "EFFICACY OF IVERMECTIN POUR-ON AGAINST OSTERTAGIA OSTERTAGI INFECTION AND RESIDUES IN THE AMERICAN BISON, BISON BISON," Journal of Wildlife Diseases 31(1), 62-65, (1 January 1995). https://doi.org/10.7589/0090-3558-31.1.62
Received: 15 December 1993; Published: 1 January 1995
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