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1 July 2006 Oral Transmission of Chronic Wasting Disease in Captive Shira's Moose
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Abstract

Three captive Shira's moose (Alces alces shirasi) were orally inoculated with a single dose (5 g) of whole-brain homogenate prepared from chronic wasting disease (CWD)–affected mule deer (Odocoileus hemionus). All moose died of causes thought to be other than CWD. Histologic examination of one female moose dying 465 days postinoculation revealed spongiform change in the neuropil, typical of transmissible spongiform encephalopathy. Immunohistochemistry staining for the proteinase-resistant isoform of the prion protein was observed in multiple lymphoid and nervous tissues. Western blot and enzyme-linked immunosorbent assays provided additional confirmation of CWD. These results represent the first report of experimental CWD in moose.

Kreeger, Montgomery, Jewell, Schultz, and Williams: Oral Transmission of Chronic Wasting Disease in Captive Shira's Moose
Terry J. Kreeger, D. L. Montgomery, Jean E. Jewell, Will Schultz and Elizabeth S. Williams "Oral Transmission of Chronic Wasting Disease in Captive Shira's Moose," Journal of Wildlife Diseases 42(3), (1 July 2006). https://doi.org/10.7589/0090-3558-42.3.640
Received: 5 August 2005; Accepted: ; Published: 1 July 2006
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