A 7.5-yr-old female southern white rhinoceros (Ceratotherium simum simum) aborted spontaneously at approximately 13 mo gestation. The fetus exhibited malformations consistent with schistosomus reflexus syndrome, including spinal inversion and ventral midline abdominal defect with externalization of abdominal viscera. A computed tomography was performed and revealed severe scoliosis, a spiral rotation of the spine, multiple vertebral anomalies, hypoplasia of multiple bones of the skull, and mild prognathism. This is the first report of schistosomus reflexus–like syndrome in a nondomestic species, and the first report to characterize these skeletal changes by three-dimensional computed tomography.