Mountains are hotspots of climate and land use change. The Hindu Kush–Himalayan (HKH) region features some of the world's most vulnerable ecosystems and is highly susceptible to climate change. Both climate change and land use transition in the HKH region have impacts on human health. A warming trend is driving the geographical expansion of disease outbreaks, whereas ecological changes and economic inequalities influence the spread of diseases. Altered distributions of vector species are early signs of climate change, and pests, pathogens, and parasites are among the first scourges to emerge during periods of transition. The distribution and seasonal transmission of vector-borne infections among humans may be affected by climate change. Information on the impacts of such changes on human health in the region is scanty. This article reviews literature on the impacts of climate change and land use transition on human health in the HKH region, specifically dealing with topics such as the relationship between climate change and health; health sensitivity, vulnerability, and adaptation; health determinants related to climate change; temperature extremes and health issues; air pollution, black carbon, and health; food security, nutrition, and health; land use change and infectious diseases; and population migration and livelihood transition. The article outlines an agenda for future research on climate change and human health for the HKH region.