The International Centre for Integrated Mountain Development (ICIMOD) supports regional and transboundary cooperation to meet challenges of climate change, disaster risks, and sustainable development in the Hindu Kush–Himalaya (HKH). Action to sustain the HKH has the potential to directly improve the lives of more than one fourth of the world's population. However, facilitating cooperation and policy coherence among the countries sharing HKH resources is a persistent challenge in a region that is prone to conflict and is highly variable regarding development. At ICIMOD, we work across HKH countries to help attain common goals related to sustainable development, using our skills in bringing together different groups within programmatic transboundary approaches covering topics such as river basins or transboundary landscapes. In addition, the Hindu Kush Himalayan Monitoring and Assessment Programme and the Himalayan University Consortium have made strides in promoting regional and transboundary cooperation among HKH countries, particularly emphasizing research synthesis and the role of academia.