We describe two new species of mice of the endemic Philippine genus Apomys, subgenus Megapomys. One is from Lubang Island, a small oceanic island off the southwest coast of Luzon, and the other is from Mt. Irid, a peak in the Southern Sierra Madre that lies northeast of Manila on Luzon Island. We also report the first specimens of Apomys sacobianus to be seen since the holotype was captured in 1956 at the foot of Mt. Pinatubo; our specimens were obtained subsequent to the eruption of Mt. Pinatubo in 1991, demonstrating the continued existence of this species. Speciation within Apomys (Megapomys) has contributed substantially to the high level of mammalian diversity and fine-scaled endemism observed on Luzon and adjacent Philippine islands.