The aim of this study was to investigate the influence of 50 Hz magnetic or static magnetic fields of 0.5 mT on subsets of human CD4 T cells in terms of cytokine release/content, cell proliferation and intracellular free calcium concentration. CD4 T cells can be divided into different subsets on the basis of surface marker expression, such as CD45, and T cells can be divided into naive (CD45RA ) and memory (CD45RA−) cells. In this study, the effects of magnetic fields after 24 and 48 h of cell culture were analyzed. We found that the CD4 CD45RA− T subset were more sensitive after 2 h of exposure. Decreases in the release/content of IFN-γ, in cell proliferation and in intracellular free calcium concentrations were observed in exposed CD4 CD45RA− T cells compared to CD4 CD45RA T cells. The results suggest that exposure to the magnetic fields induces a delay in the response to stimulants and that modifications are rapidly reversible, at least after a short exposure.
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1 October 2009
Reversible Effect of Magnetic Fields on Human Lymphocyte Activation Patterns: Different Sensitivity of Naive and Memory Lymphocyte Subsets
Sergio Salerno,
Carmela La Mendola,
Marco Pio La Manna,
Antonio Lo Casto,
Nadia Caccamo,
Alfredo Salerno
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