Phacepholis Horn is a lineage of the Pantomorus-Naupactus complex (Curculionidae: Entiminae: Naupactini) that evolved in North and Central America independently from the species traditionally assigned to Pantomorus Schoenherr. The genus includes 13 species, five distributed in North America and eight in Mexico and Central America. The Mexican-Central American species are Phacepholis globicollis (Pascoe), Phacepholis brevipes (Sharp), Phacepholis trituberculatus (Champion), Phacepholis albicans (Sharp), Phacepholis viridicans (Sharp), Phacepholis strabo (Sharp), Phacepholis howdenae Lanteri and del Río, new species (type locality: Zacapa, Guatemala) and Phacepholis burkei Lanteri and del Río, new species (type locality: Guerrero, Mexico). Phacepholis annectens (Sharp) is a junior synonym of P. brevipes, new synonymy. Lectotypes are designated for Pantomorus brevipes Sharp, Pantomorus annectens Sharp, Pantomorus trituberculatus Champion, Pantomorus albicans Sharp, and Pantomorus viridicans Sharp. Among the eight species of the P. globicollis species-group, six species are endemic to Mexico and two, P. strabo and P. howdenae, range into Central America. The Neotropical Phacepholis mainly differ from the Nearctic species by being larger, with longer antennae, the more convex male pronotum, and the spermathecae subglobose rather than globose. We provide descriptions or redescriptions of the eight species of Phacepholis from Mexico and Central America, a dichotomous key for their identification, habitus photographs, line drawings of male and female genitalia, and distribution maps.