Land use by Indigenous people (Native Americans) and climate are primary factors affecting the dynamics of oak (Quercus) forests and woodlands in the eastern United States. Prior to Euro-American settlement, much of the eastern deciduous forest was dominated by oak species. The role of periodic surface burning, agriculture, and other forms of land management by Indigenous peoples is frequently noted by cultural anthropologists and historical ecologists. However, these points are often debated by paleoecologists and climate scientists. Here we present a literature review, synthesis, and data summary to investigate the role of altered land use, season of burning, and climate change in relation to pre– and post–Euro-American changes in forest composition. Human-based ignitions, as reflected by dormant-season fires, prevailed over the oak- and pine-dominated forests, with intermediate fire frequency during Indigenous periods. From the 18th century on, Euro-American populations rapidly expanded, impacting much of the eastern United States through extensive timber harvesting, land clearing, and severe fires. Starting in the 20th century, a variety of ecological influences, including agricultural land abandonment, chestnut blight, fire suppression, mesophication, and urbanization, resulted in dramatic vegetation changes in eastern landscapes. These trends have culminated in recruitment failures of most oak species on all but the most xeric sites and an increase in mid- to late-successional mesic hardwoods, most notably red maple (Acer rubrum), a species with very low density in our analysis of the witness tree record. We conclude that prescribed burning, agriculture, and other land uses by Indigenous peoples created a mosaicked landscape of expansive oak savannas, woodlands, and forests. A warming world over the past century should have promoted warm-adapted, fire-tolerant, xerophytic genera such as oak, hickory (Carya), and pine (Pinus) and grassland communities but instead have promoted the invasion by cool-adapted, fire-sensitive, mesophytic trees due to the absence of burning, much to the detriment of major vegetation biomes. Understanding that eastern oak and other pyrogenic ecosystems represent an Indigenous landscape strengthens our ability to best manage vegetation against the expansion of less desirable species and restore historic fire cycles through prescribed burning.