A new genus, Zanelopona, is described that is closely related to Hecalapona DeLong and Freytag. Included in the genus are four species previously described in either Hecalapona or Gypona. They are Zanelopona summita (DeLong and Kolbe).new combination, Z. supina (DeLong and Freytag) new combination, Z. antlerita (DeLong and Kolbe) new combination, and Z. huella (DeLong and Freytag) new combination; and twenty new species as follows; Z. calcara, Z. campana, Z. labella, Z. liberata, Z. limba, Z. marea, Z. proceta, and Z. prodigiosa from Colombia; Z. quadrata from Colombia and Ecuador; Z. dilata, and Z. lacerta from Ecuador; Z. doleta, Z. incisa, Z. megalota, and Z. torula from Brazil; Z. anomala, Z. dasida, and Z. juba from Peru; Z. incita from French Guiana; and Z. intensa from Venezula . All species of this new genus are from the northern part of South America down to Peru.