The success of biodiversity conservation in African countries depends to a large extend on the cooperation of local communities. This study compared factors that influence attitudes of local communities toward the conservation of the Tarangire National Park (Tarangire NP) in Tanzania and Mole National Park (Mole NP) in Ghana. The purpose was to find out if the predominantly agricultural-communities around the Mole NP in Ghana will differ in park-attitude than the predominantly pastoral-communities around the Tarangire NP in Tanzania. Household survey was used to assess attitudes and focus group discussions used to elicit further information from respondents to complement the survey data. The study surveyed 365 households in 7 villages: 3 villages adjacent to the Tarangire NP and 4 villages adjacent to the Mole NP. There was significant difference between the park-attitudes of residents in communities near the Mole NP and their counterparts in communities near the Tarangire NP. However, respondents in both countries showed slightly positive and negative attitudes toward the parks as ecological entities and as community development agents, respectively. Factors that had significant effects on attitudes include: “knowledge of park rules,” “employment in park,” “distance between village and park,” “household size,” “access to non-timber forest products,” and “livelihood activity.” The findings suggest that any efforts aimed at increasing local community support for any of the two national parks should critically consider livelihoods diversification, population control, and extensive conservation education in neighboring communities.