Trifludimoxazin is a new herbicide that inhibits protoporphyrinogen oxidase and is being evaluated for the control of small-seeded annual broadleaf weeds and grasses in several crops. Currently, no information is available regarding peanut cultivar response to trifludimoxazin and its utility in peanut weed control systems. Three unique field experiments were conducted and replicated in time from 2019 through 2022 to determine the response of seven peanut cultivars (‘AU-NPL 17’, ‘FloRun 331’, ‘GA-06G’, ‘GA-16HO’, ‘GA-18RU’, ‘GA-20VHO’, and ‘TifNV High O/L’) to preemergence applications of trifludimoxazin and to determine the efficacy of trifludimoxazin at multiple rates and tank-mixtures with acetochlor, diclosulam, dimethenamid-P, pendimethalin, and S-metolachlor for weed management. Cultivar sensitivities to trifludimoxazin were not observed. Peanut density was not reduced by any trifludimoxazin rate. Compared with nontreated controls, in 2019 when trifludimoxazin was applied at 75 g ai ha^–1, leaf necrosis increased by 18% and peanut stunting increased by 10%, and yield was reduced by 6%. However, this rate increased leaf necrosis by only 4%, stunting by 3% to 5%, and it had no negative effect on yield in 2020–2021. Generally, peanut injury from preemergence-applied trifludimoxazin was similar to or less than that observed from flumioxazin at 2 wk after application (WAA). Peanut yield in the weed control study was reduced by 11% to 12% when treated with trifludimoxazin at 150 g ha^–1 (4× the standard rate) when compared to the 75 g ha^–1 rate. However, yield was not different from the flumioxazin treatment. Palmer amaranth control with trifludimoxazin combinations was ≥91% at 13 WAA, wild radish control was ≥96% at 5 WAA, and annual grass control was ≥97% at 13 WAA. Peanut is sufficiently tolerant of 38 g ha^–1 of trifludimoxazin, and when tank-mixed with other residual herbicides provides weed control similar to flumioxazin-based systems.

Nomenclature: Acetochlor; diclosulam; dimethenamid-P; flumioxazin; pendimethalin; S-metolachlor; trifludimoxazin; Palmer amaranth; Amaranthus palmeri S. Watson AMAPA; wild radish; Raphanus raphanistrum L. RAPRA; peanut; Arachis hypogaea L.