During the spring of 2006, we observed predation by California whiptail (Aspidoscelis tigris munda) on the endemic coastal roach (Hesperoleucus venustus) from an isolated pool along an intermittent reach of Coyote Creek, Santa Clara County, California, USA. Our observation is the first published record, to the best of our knowledge, of a whiptail in the genus Aspidoscelis in the southwestern United States preying upon fish. We also report on subsequent observations during 2014, 2015, and 2020 of California whiptail foraging along isolated, intermittent stream pools within this watershed.