How to translate text using browser tools
1 October 2016 Regeneration of Murine Hair Follicles is Inhibited by Low-Dose-Rate Gamma Irradiation
Kimihiko Sugaya, Tomohisa Hirobe, Yoshie Ishihara, Sonoe Inoue
Author Affiliations +

To determine whether the effects of low-dose-rate gamma (γ) irradiation are identifiable in the regeneration of murine hair follicles, we irradiated whole bodies of C57BL/10JHir mice in the first telogen phase of the hair cycle with 137Cs γ-rays. The mice were examined for effects on hair follicles, including number, morphology, and pigmentation in the second anagen phase. Effects of γ-radiation on melanocyte stem cells were also investigated by the indirect immunolabeling of tyrosinase-related protein 2 (TRP2). Irradiated skin showed a decrease in hair follicle density and the induction of curved hair follicles along with the presence of white hairs and hypopigmented hair bulbs. There was a small, but not significant, change in the number of TRP2-positive melanocyte stem cells in the hair bulge region of the irradiated skin. These results suggest that low-dose rate γ-irradiation does not deplete melanocyte stem cells, but can damage stem cells and progenitors for both keratinocytes and melanocytes, thereby affecting the structure and pigmentation of regenerated hair follicles in the 2nd anagen phase.

© 2016 Zoological Society of Japan
Kimihiko Sugaya, Tomohisa Hirobe, Yoshie Ishihara, and Sonoe Inoue "Regeneration of Murine Hair Follicles is Inhibited by Low-Dose-Rate Gamma Irradiation," Zoological Science 33(5), 461-466, (1 October 2016).
Received: 11 March 2016; Accepted: 1 May 2016; Published: 1 October 2016
hair cycle
Stem cell
Get copyright permission
Back to Top