Polysaccharide from Scutellaria baicalensis Georgi alleviates ulcerative colitis in mice by maintaining the intestinal barrier integrity via MLC/Notch signaling

Liang Xiao; Yongpo Chen; Xiaoqing Li; Shuwei Li; Wenjie Tang; Jiayou Yan; Xiaolan Wei; Mengjia Zhou; Chongbo Huang; Hui Diao

doi:10.1139/cjas-2024-0020

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Liang Xiao,¹ Yongpo Chen,² Xiaoqing Li,³ Shuwei Li,^4,5 Wenjie Tang,^4,6 Jiayou Yan,^4,6 Xiaolan Wei,^4,6 Mengjia Zhou,^4,6 Chongbo Huang,^4,6 Hui Diaohttps://orcid.org/0000-0001-9121-6875^4,6,*

¹Hunan A-Long-Win Biotechnology Co., Ltd., Changsha 410014, Hunan, People's Republic of China
²Sichuan Chelota Biotech Co., Ltd., Deyang 618302, Sichuan, People's Republic of China
³Agriculture and Rural Affairs of Xiangdong District, Pingxiang 337016, Jiangxi, People's Republic of China
⁴Animal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Academy of Animal Science, Chengdu 610066, Sichuan, People's Republic of China
⁵Sichuan Animtech Biology Development Co., Ltd., Chengdu 611330, Sichuan, People's Republic of China
⁶Livestock and Poultry Biological Products Key Laboratory of Sichuan Province, Sichuan Animtech Group Co., Ltd., Chengdu 610066, Sichuan, People's Republic of China

^*Corresponding author: Hui Diao (email: diao_hui@hotmail.com)

Abstract

Ulcerative colitis is a chronic idiopathic inflammatory bowel disease (IBD) that seriously impacts human health. So far, little information has been reported on the possible benefits of polysaccharides from Scutellaria baicalensis Georgi (SBGP) in alleviating colitis. Therefore, our study investigated the potential therapeutic effects of SBGP on mice with DSS-induced colitis. Results showed that SBGP administration ameliorated the severity of clinical symptoms and enhanced immunomodulatory effects in dextran sulfate sodium (DSS)-treated mice. Additionally, SBGP was found to regulate the inflammatory response, improve mucosal barrier integrity, and maintain tight junctions in the colonic epithelium. Furthermore, SBGP was found to restrain the activation of Notch and MLCK/MLC signaling pathways, which play important roles in inflammation and epithelial barrier homeostasis. These findings suggest that SBGP may have therapeutic potential for the treatment of colitis and other IBD.

Citation Download Citation

Liang Xiao, Yongpo Chen, Xiaoqing Li, Shuwei Li, Wenjie Tang, Jiayou Yan, Xiaolan Wei, Mengjia Zhou, Chongbo Huang, and Hui Diao "Polysaccharide from Scutellaria baicalensis Georgi alleviates ulcerative colitis in mice by maintaining the intestinal barrier integrity via MLC/Notch signaling," Canadian Journal of Animal Science 105(1), 1-12, (27 January 2025). https://doi.org/10.1139/cjas-2024-0020

Received: 17 February 2024; Accepted: 29 August 2024; Published: 27 January 2025