Awawdeh, M. S., Talafha, A. Q. and Obeidat, B. S. 2015. Postpartum injection with vitamin E and selenium failed to improve the performance of Awassi ewes and their lambs. Can. J. Anim. Sci. 95: 111-115. The objective of this study was to investigate the effect of vitamin E and Se injection of nursing Awassi ewes on the performance of ewes (body weight change, milk yield, and composition) and their lambs (growth rate and weaning weight). Twenty-eight Awassi ewes were randomly assigned upon lambing to one of two groups; Control (n=13) and Inject (n=15), where ewes received 0 (control) or 15 plus 0.05 mg kg^-1 BW of vitamin E and Se, respectively (inject). Intramuscular injections were given at 1 and 4 wk postpartum. Body weight (BW) of ewes and their lambs were recorded at lambing and at 2, 4, 6, and 8 wk postpartum. Milk yield and composition were measured at 2, 4, and 6 wk postpartum and somatic cell count (SCC) was evaluated weekly (from lambing through 8 wk). Injecting nursing ewes with vitamin E and Se had no effects (P≥0.10) on BW change of ewes, milk yield and composition, composition yields, or milk SCC. Injecting nursing ewes with vitamin E and Se had no significant effects (P≥0.29) on weaning weight, BW gain, or growth rate of their lambs. Under conditions similar to the current study, injecting nursing Awassi ewes with vitamin E and Se at 1 and 4 wk postpartum was not effective in improving the performance of ewes and their suckling lambs. Such observations could be attributed to the time of supplementation (pre- or post-partum) and/or the adequate basal vitamin E status in ewes.