Soil health encompasses the collective functioning of chemical, physical, and biological properties in soil. The extent to which soil management affects soil health and the links with agronomic outcomes remain unclear. This project aimed to understand the interrelations of tillage systems, soil health, and agronomic properties in Portage la Prairie, MB, Canada. Tillage systems were cultivation, deep tillage, raised beds, and vertical tillage. Soybean (Glycine max (L.) Merr), corn (Zea mays L.), and canola (Brassica napus L.) were all grown in 2020, 2021, and 2022. Crop yield, seed protein content, and seed oil content were measured each year. Soil samples were taken in spring 2021, fall 2021, and fall 2022 and analyzed for nitrate-N, ammonium-N, total N, ACE protein, water extractable organic N, water extractable total N, water extractable ammonium N, soil organic matter, soil organic carbon, calcium carbonate equivalent, CO₂ burst, permanganate oxidizable carbon, water extractable organic C, pH, salts, Olsen P, K, S, sand, silt, and clay. Tillage system had a significant impact on agronomic properties in seven crop by sampling combinations. Tillage system effected soil nitrate-N concentration at five crop by sampling combinations, three more than any other soil property. Soybean agronomic properties correlated with soil health indicators more frequently than for corn and canola. This suggests that the utility of soil health indicators may be crop specific. Further research is needed to understand the mechanisms underpinning the ability of soil health indicators to predict agronomic outcomes and to benchmark soil health indicator values with time.