The fate of the mummies of the Inca kings following the Spanish conquest of Peru has been the focus of more than a century of historical and archaeological research. Several lines of evidence indicate that five of the royal mummies were deposited in the Hospital of San Andrés in Lima in 1560. In this work, we summarize what is currently known concerning the fate of the royal Inca mummies as well as the results of a recent ground-penetrating radar survey and an archaeological testing program that we conducted on the hospital grounds. The excavations revealed the location of the hospital's first cemetery, the remains of a nineteenth-century fountain, an early colonial trash pit, and, most intriguingly, a vaulted structure. While we did not find the royal mummies, the historical research and archaeological fieldwork yielded new information on the history of the San Andrés compound and life in Lima during early colonial times.