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9 August 2022 Pharmacokinetics and Egg Residues of Oral Meloxicam in Bantam Cochin Chickens
C. Robert Stilz, Sherry Cox, Joan Bergman, Lillian Gerhardt, Sarah Singleton, Lainey Harvill, Marcy J. Souza
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Abstract

Backyard poultry are commonly treated in veterinary hospitals; however, there is limited information regarding appropriate dosing of medications and withdrawal times for eggs. Six healthy adult bantam Cochin hens were given a single oral dose of meloxicam (1 mg/kg). Meloxicam plasma concentrations and egg residues were analyzed by high-performance liquid chromatography. Noncompartmental analysis was used to calculate pharmacokinetic parameters. The apparent terminal half-life, maximum concentration, and time to maximum concentration were 5.94 ± 0.92 hours, 7.03 ± 2.68 µg/mL, and 2.83 ± 1.33 hours, respectively. Meloxicam was detected in egg whites for 4.8 ± 1.5 days and egg yolks for 9.8 ± 2.4 days. Results were compared with previous studies in white leghorn and Columbian Wyandotte hens. Bantam Cochin hens demonstrated a significantly longer mean apparent terminal half-life, greater area under the curve, smaller elimination rate constant, and longer egg residue times compared with white leghorn hens. However, the pharmacokinetic results from the bantam Cochin hens did not significantly differ from those reported for the Columbian Wyandotte hens. Until pharmacodynamic studies can be performed, dosing of oral meloxicam in bantam Cochins should follow recommendations for Columbian Wyandotte hens to reduce the likelihood of adverse effects. These results better inform appropriate dosing of meloxicam in domestic hens, as well as recommended withdrawal times for egg consumption.

© 2022 by the Association of Avian Veterinarians
C. Robert Stilz, Sherry Cox, Joan Bergman, Lillian Gerhardt, Sarah Singleton, Lainey Harvill, and Marcy J. Souza "Pharmacokinetics and Egg Residues of Oral Meloxicam in Bantam Cochin Chickens," Journal of Avian Medicine and Surgery 36(2), 140-144, (9 August 2022). https://doi.org/10.1647/21-00023
Published: 9 August 2022
KEYWORDS
Avian
backyard poultry
bantam Cochin
egg residue
meloxicam
pharmacokinetics
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