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1 September 2015 Larvicidal and Biting Deterrent Activity of Essential Oils of Curcuma longa, Ar-turmerone, and Curcuminoids Against Aedes aegypti and Anopheles quadrimaculatus (Culicidae: Diptera)
Abbas Ali, Yan-Hong Wang, Ikhlas A. Khan
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Abstract

Essential oils and extract of Curcuma longa, ar-turmerone, and curcuminoids were evaluated for their larvicidal and deterrent activity against mosquitoes. Ar-turmerone and curcuminoids constituted 36.9, 24.9 and 50.6% of rhizome oil, leaf oil, and rhizome extract, respectively. Ar-turmerone was the major compound of the rhizome oil (36.9%) and leaf oil (24.9%). The ethanolic extract had 15.4% arturmerone with 6.6% bisdesmethoxycurcumin, 6.1% desmethoxycurcumin, and 22.6 % curcumin. In in vitro studies, essential oils of the leaf (biting deterrence index [BDI] = 0.98), rhizome (BDI = 0.98), and rhizome ethanolic extract (BDI = 0.96) at 10 μg/cm2 showed biting deterrent activity similar to DEETat 25 nmol/cm2 against Aedes aegypti L. Among the pure compounds, ar-turmerone (BDI = 1.15) showed the biting deterrent activity higher than DEETat 25 nmol/cm2 whereas the activity of other compounds was lower than DEET. In Anopheles quadrimaculatus Say, only ar-turmerone showed deterrent activity similar to DEET. In dose—response bioassay, ar-turmerone showed significantly higher biting deterrence than DEETat all the dosages. Ar-turmerone, at 15 nmol/cm2, showed activity similar to DEET at 25 nmol/cm2 and activity at 5 nmol/cm2 was similar to DEETat 20 and 15 nmol/cm2. Leaf essential oil with LC50 values of 1.8 and 8.9 ppm against larvae of An. quadrimaculatus and Ae. aegypti, respectively, showed highest toxicity followed by rhizome oil and ethanolic extract. Among the pure compounds, arturmerone with LC50 values of 2.8 and 2.5 ppm against larvae of An. quadrimaculatus and Ae. aegypti, respectively, was most toxic followed by bisdesmethoxycurcumin, curcumin, and desmethoxycurcumin.

© The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America.
Abbas Ali, Yan-Hong Wang, and Ikhlas A. Khan "Larvicidal and Biting Deterrent Activity of Essential Oils of Curcuma longa, Ar-turmerone, and Curcuminoids Against Aedes aegypti and Anopheles quadrimaculatus (Culicidae: Diptera)," Journal of Medical Entomology 52(5), 979-986, (1 September 2015). https://doi.org/10.1093/jme/tjv072
Received: 3 March 2015; Accepted: 26 May 2015; Published: 1 September 2015
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KEYWORDS
Curcuna longa
deterrent
essential oil
extract
larvicide
mosquito
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