Integrating the landscape pattern holistically and identifying priority areas for ecological restoration scientifically are the key challenges of national land space planning and ecological protection. Taking Xiushui County, a fragile ecological region in the south, as an example, this study established an evaluation index system based on the pattern-process principle, including the importance of ecosystem services and ecosystem sensitivity, and explored regional priority areas for ecological restoration through GIS spatial analysis technology. The results show that the ecological restoration priority area in the case study area is 2880.64 km² in total, covering 63.93% of the overall area. Of that amount, 367.55 km² is the bottom-line priority areas for ecological restoration, accounting for 8.16%. Regarding land use types within the major ecological restoration priority area, the arable land and construction land areas are 210.83 km² and 122.52 km², covering 55.35% and 51.43% of the overall area, respectively. Determining the priority areas at different levels can help decision-makers to prioritize the restoration needs of degraded areas and provide a basis for adopting targeted ecological restoration measures for areas with different degrees of degradation. Identifying priority areas also provides basic information for the protection and construction of the eco-security pattern of the territorial space, which is vital for improving the regional ecological environmental safety and building a harmonious community between humans and nature.