Mauritania, located in the Western Sahara, is one of the least developed countries in the Sahara Desert. Its capital, Nouakchott, which is home to 23% of its population, suffers from soil erosion from the Sahara and salt-water intrusion from the Atlantic Ocean. The local environment is under pressure from the combined effects of climate and socio-economic factors, with desertification being recognized as the greatest threat to life. In this context, high-resolution remote sensing images of Nouakchott obtained during the winters of 1985, 1988, 2000, 2006, and 2010 are selected for interpretation and classification. Analysis of the types of desertification and land use reveals the temporal and spatial characteristics of five distinct time periods from 1985 to 2010. This study analyzes the current status of desertification in Nouakchott and suggests five preventive measures.