This article describes the timing of gametogenic development and spawning in a population of geoduck clams, Panopea globosa (Dall 1898), from the Upper Gulf of California and its relationship to temperature changes and primary productivity. Clams were collected monthly over 1 year (March 2008 to March 2009), and salinity, dissolved oxygen, and substrate type were recorded during each survey. Standard histological analyses and measurements of oocyte diameters were used to describe the timing of gametogenic development and spawning. Satellite data for temperature and chlorophyll were gathered to test a general conceptual planktonic larval development model. The results demonstrated that reproductive activity was triggered by a steep decrease in temperature 4 months prior to the peak of productivity. Thus, larval development matches favorable conditions, as predicted by Cushing's Match—Mismatch Hypothesis.