Infections in channel catfish (Ictalurus punctatus, Rafinesque) induced by the sporozoan Henneguya (Protozoa: Myxosporidea) result in seven known and diverse disease manifestations. Most outstanding is an interlamellar branchial form responsible for significant losses among immature catfish, and a unique papillomatous form. The question of whether or not the species of Henneguya involved in these cases is H. exilis remains to be resolved.